Ipamorelin (5mg)

CAS Number: 170851-70-4

Molecular Formula: C₃₈H₄₉N₉O₅

Molecular Weight: 711.85 g/mol

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (5 amino acids)

What Is Ipamorelin?

Ipamorelin (INN; development code NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue. Wikipedia It is a lab-made pentapeptide designed to activate the ghrelin receptor, triggering short, pulsatile releases of growth hormone (GH). Unlike earlier GH-releasing peptides, ipamorelin was designed to be more selective — it stimulates GH without reliably raising cortisol or prolactin in research settings. VitaLibrary

Originally developed by Novo Nordisk in the late 1990s, ipamorelin represents one of the most selective growth hormone-releasing peptides (GHRPs) available, demonstrating minimal activation of secondary hormone pathways compared to other compounds in its class. Paragonsportsmedicine It was investigated in Phase II clinical trials by Helsinn Therapeutics for the treatment of postoperative ileus, but was discontinued due to lack of efficacy. It is currently commonly marketed as a research peptide rather than as an approved pharmaceutical drug. Wikipedia

Areas of Active Research:

1. Muscle Growth & Recovery 🏋️

Research indicates potential benefits through enhanced protein synthesis, increased satellite cell activation, and improved muscle fiber regeneration through IGF-1-mediated pathways. Paragonsportsmedicine

2. Fat Loss & Metabolic Enhancement 🔥

Ipamorelin supports fat breakdown (lipolysis) and may help reduce stubborn body fat while preserving muscle mass. Nulevel Wellness Medspa By promoting the breakdown of adipose tissue and increasing energy expenditure, it may support weight loss efforts and aid in maintaining a healthy body composition. Carbonworldhealth

3. Bone Density & Skeletal Health 🦴

Ipamorelin has been shown to counteract the glucocorticoid-induced decrease in bone formation in adult rats. MuseChem IGF-1-mediated stimulation of osteoblast proliferation and enhanced collagen synthesis in bone matrix are proposed mechanisms for bone metabolism enhancement. Paragonsportsmedicine

4. Sleep Quality 😴

GH is secreted primarily during slow-wave sleep, and ipamorelin creates a bidirectional relationship — it amplifies the GH pulse during sleep and may independently improve sleep depth and duration. PeptideDeck

5. Tissue Repair & Recovery 🩹

Connective tissue repair, injury healing, and post-workout recovery are all areas of interest due to elevated GH and IGF-1. PeptideDeck

6. Anti-Aging & Skin Health 🧴

Some early research and anecdotal reports suggest that increased growth hormone activity may improve skin elasticity, helping to reduce visible signs of aging. Bone health may also benefit, which is especially important for older adults concerned about osteoporosis or joint strength. Dianarangaves

7. Cognitive Function & Mood 🧠

Some studies suggest Ipamorelin has neuroprotective effects, potentially helping with focus, memory, and mood balance. Nulevel Wellness Medspa

8. GI Motility & Postoperative Ileus

Ipamorelin has been shown to accelerate gastric emptying in a rodent model of postoperative ileus through the stimulation of gastric contractility by activating a ghrelin receptor-mediated mechanism involving cholinergic excitatory neurons. MuseChem

9. Insulin & Pancreatic Function 🩸

Ipamorelin is a pentapeptide with strong growth hormone releasing potency that evokes insulin release from the pancreas of both normal and diabetic rats. ChemicalBook